Growth‐Factor Free Multicomponent Nanocomposite Hydrogels That Stimulate Bone Formation

Graphene and hydroxyapatite self-assemble into homogeneous, free standing nanocomposite hydrogels for bone tissue engineering.

Graphene-nanoparticle (NP) composites have shown potential in applications ranging from batteries to, more recently, tissue engineering. Graphene and NPs should be integrated into uniform free-standing structures for best results. However, to date, this has been achieved only in few examples; in most cases, graphene/NP powders lacking three-dimensional (3D) structure were produced. Here we repo...

Does simvastatin stimulate bone formation in vivo?

BACKGROUND Statins, potent compounds that inhibit cholesterol synthesis in the liver have been reported to induce bone formation, both in tissue culture and in rats and mice. To re-examine potential anabolic effects of statins on bone formation, we compared the activity of simvastatin (SVS) to the known anabolic effects of PTH in an established model of ovariectomized (OVX) Swiss-Webster mice. ...

Nanocomposite hydrogels for biomedical applications.

Hydrogels mimic native tissue microenvironment due to their porous and hydrated molecular structure. An emerging approach to reinforce polymeric hydrogels and to include multiple functionalities focuses on incorporating nanoparticles within the hydrogel network. A wide range of nanoparticles, such as carbon-based, polymeric, ceramic, and metallic nanomaterials can be integrated within the hydro...

Polymer Nanocomposite Hydrogels for Water Purification

PVA–clay nanocomposite hydrogels for wound dressing

Polymer gels as soft biomaterials have found diverse applications in biomedical field, e.g. in management and care of wound as wound dressing. The recent researches on nanocomposite materials have shown that some properties of polymers and gels significantly improve by adding organoclay into polymeric matrix. In this work, in order to obtain wound dressing with better properties, nanocomposite ...